Sickle Cell Disease

Michael Cruz
reap hook Cell Disease
Cell Biology BIOL 2420 A
Dr. Ben Johnson
November 21, 2011

Introduction:
Sickle cell disease is an inherited disorder in which the proboscis makes sickle- findd red blood line cells. The sickle-shape refers to the abnormal crescent shape of the red blood cells; normal red blood cells argon shaped like a disc. harmonize to the National Institutes of health (2011), sickle cell anemia, also known as haemoglobin SS disease, is the most common form of sickle cell disease. Hemoglobin, the corpuscle in red blood cells that carries oxygen to other soundbox cells, is affected by sickle cell disease because sickle cells contain abnormal haemoglobin. This atypical hemoglobin is called sickle hemoglobin, or hemoglobin S, and it distorts the shape of red blood cells, especially when undefendable to depleted oxygen levels (National Center for Biotechnology Information, 2010). At the molecular level, a single nucleotide change causes a mutated ?-globin, unitary of the two types of subunit that form hemoglobin (Alberts et al., 2010). This, in turn, causes a change in the amino acid sequence of the hemoglobin protein.



The research in this paper will explore the version that causes sickle cell disease, the molecular mechanism of the disease, signs and symptoms, complications, epidemiology of the disease, treatment, and ethical issues come to with the treatment of sickle cell anemia.
Body:
Humans employ the protein hemoglobin to transport oxygen in the blood to the major organ systems of the body. A permanent change in a single nucleotide triggers blood cells to make hemoglobin with an ill-advised sequence of amino acids, and sickle cell anemia results from this mutation. According to Phill Jones, a doctor in physiology and pharmacology, the sickle cell hemoglobin is less soluble than normal hemoglobin and forms fibrous precipitates, which modernise the characteristic sickle shape of affected red blood cells (2008). Sickle-shaped red blood cells are fragile and...If you regard to get a full essay, order it on our website: Orderessay



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