Kupffer Cells "Sinusoidal cells"

This proximity to the portal venous blood vessel allows Kupffer cells to monitor the blood which enters the sinusoid. Perhaps the most distinctive distinctive of these cells is their ability to phagocytize large particles. In fact, one of the Kupffer cells' functions erythrophagocytosis. They gather in been cognise to phagocytize latex particles ranging in size up to 0.8 and 1 micrometer caliper (2:495).

Typically, Kupffer cells line the lumen of the sinusoids; thus they tend to lie o'er the endothelium. They attach themselves to this surface through cytoplasmic processes that pass may between the fenestrations and penetrate into the endothelial cell cytoplasm, extending into the space of Disse (5:50). However, no junctional attachments exist between Kupffer cells and the endothelial cells (3:508).

The individual cells themselves each have a cell coat that consists of two layers. The inner layer, which lies stodgy to the plasma membrane, may consist of glycoproteins and glycolipids. The thick outer layer, which reacts for protein, is 50 to 70 nanometers in thickness. It is often described as cosmos filamentous or fuzzy.

It has been suggested that these cell coats contain receptors for antibodies and complement.

Other indication structures of Kupffer cells include bristlecoated micropinocytotic vesicles and wormlike structures. The micropinocytotic vesicles ar able to take up particles 3.5 to 7.5 nanometers i

1. Billiar, T. R.; Curran, R. D. Kupffer cell and hepatocyte interactions: A brief overview. Jpen. Journal of Parenteral and enteral Nutrition. 14:175S180S; 1990, SeptemberOctober.

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